278788-66-2
- Product Name：(R)-1-Boc-3-hydroxymethylpiperazine
- Molecular Formula：C10H20N2O3
- Purity：99%
- Molecular Weight：216.28
Product Details
Chinese Manufacturer supply (R)-1-Boc-3-hydroxymethylpiperazine 278788-66-2 in stock with high standard
- Molecular Formula:C10H20N2O3
- Molecular Weight:216.28
- Vapor Pressure:2.15E-05mmHg at 25°C
- Refractive Index:1.477
- Boiling Point:322.9 °C at 760 mmHg
- PKA:14.97±0.10(Predicted)
- Flash Point:149.1 °C
- PSA：61.80000
- Density:1.085 g/cm3
- LogP:0.45430
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(Cas 278788-66-2) Usage
InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1
278788-66-2 Relevant articles
FARNESYL PROTEIN TRANSFERASE INHIBITORS
-
Page/Page column 35, (2010/02/11)
Disclosed are compounds of formula (1.0)...
278788-66-2 Process route
-
-
173774-50-0
N-Boc-piperazine-2-amidoanhydride
-
-
278788-66-2
(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate
| Conditions | Yield |
|---|---|
|
With
sodium tetrahydroborate;
In
ethanol;
for 48h;
Heating / reflux;
|
50% |
-
-
278788-66-2
(R)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate
-
-
1450620-51-5
tert-butyl (3aR)-1-oxotetrahydro-1H-1λ4-[1,2,3]oxathiazolo[3,4-a]pyrazine-5(3H)-carboxylate
| Conditions | Yield |
|---|---|
|
With
1H-imidazole; thionyl chloride;
In
dichloromethane;
at -70 - 15 ℃;
for 13h;
|
95.6% |
|
With
1H-imidazole; thionyl chloride;
In
dichloromethane;
at -70 - 15 ℃;
|
95.6% |
|
With
1H-imidazole; thionyl chloride; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
for 72.3333h;
|
86% |
|
With
1H-imidazole; thionyl chloride;
In
dichloromethane;
at -78 - 20 ℃;
for 18h;
|
12.23 g |
|
With
1H-imidazole; thionyl chloride;
In
dichloromethane;
at -70 - 15 ℃;
for 12h;
|
|
|
With
1H-imidazole; thionyl chloride;
In
dichloromethane;
at -78 - 25 ℃;
Inert atmosphere;
|
|
|
With
1H-imidazole; thionyl chloride;
In
dichloromethane;
at 0 - 20 ℃;
for 24h;
|
4.8 g |
278788-66-2 Upstream products
-
173774-50-0
N-Boc-piperazine-2-amidoanhydride
278788-66-2 Downstream products
-
943653-48-3
(R)-tert-butyl-3-(O-tert-butyldiphenylsilane)methyl-piperazine-1-carboxylate
-
278788-67-3
(R)-tert-butyl 3-(hydroxymethyl)-4-methylpiperazine-1-carboxylate
-
943238-14-0
1,1-dimethylethyl (3R)-4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-3-(hydroxymethyl)-1-piperazinecarboxylate
-
1147422-39-6
(R)-4-(2-chloroacetyl)-3-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester
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