189005-44-5
- Product Name：Zolpidic acid
- Molecular Formula：C17H16N2O2
- Purity：99%
- Molecular Weight：280.326
Product Details
pd_meltingpoint:243-245 °C
Appearance:Off-white to pale beige solid
Manufacturer supply high quality Zolpidic acid 189005-44-5 with GMP standards
- Molecular Formula:C17H16N2O2
- Molecular Weight:280.326
- Appearance/Colour:Off-white to pale beige solid
- Melting Point:243-245 °C
- Refractive Index:1.631
- PKA:2.87±0.10(Predicted)
- PSA：54.60000
- Density:1.224 g/cm3
- LogP:3.24520
6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid(Cas 189005-44-5) Usage
InChI:InChI=1/C17H16N2O2/c1-11-3-6-13(7-4-11)17-14(9-16(20)21)19-10-12(2)5-8-15(19)18-17/h3-8,10H,9H2,1-2H3,(H,20,21)
189005-44-5 Relevant articles
A novel formulation of zolpidem for direct nose-to-brain delivery: synthesis, encapsulation and intranasal administration to mice
Borodina, Tatiana,Marchenko, Irina,Trushina, Daria,Volkova, Yulia,Shirinian, Valerii,Zavarzin, Igor,Kondrakhin, Evgeny,Kovalev, Georgy,Kovalchuk, Mikhail,Bukreeva, Tatiana
, p. 1164 - 1173 (2018)
Objectives: Anxiolytic drug zolpidem was...
Visible-light-mediated C3-ethoxycarbonylmethylation of imidazo[1,2-a]pyridines and convenient access to Zolpidem
Xiao, Yuanjiu,Yu, Lin,Yu, Yongqi,Tan, Ze,Deng, Wei
, (2020)
-
Structure-based discovery of potent and selective small-molecule inhibitors targeting signal transducer and activator of transcription 3 (STAT3)
Huang, Qiuyao,Zhong, Yan,Li, Bingbing,Ouyang, Shumin,Deng, Lin,Mo, Jianshan,Shi, Shuo,Lv, Nan,Wu, Ruibo,Liu, Peiqing,Hu, Wenhao,Zhang, Xiaolei,Wang, Yuanxiang
, (2021/05/17)
STAT3 has been validated as an attractiv...
Synthesis of Substituted Imidazo[1,2-a]Pyridin-3-yl-Acetic Acids by Multicomponent Condensation of 2-Aminopyridines with Arylglyoxals and Meldrum’s Acid
Lichitsky, Boris V.,Tretyakov, Аleksander D.,Komogortsev, Andrey N.,Mityanov, Vitaly S.,Dudinov, Arkady А.,Krayushkin, Mikhail M.
, p. 156 - 159 (2019/03/23)
[Figure not available: see fulltext.] A ...
A method for preparing [...] (by machine translation)
-
Paragraph 0017; 0020; 0023, (2019/01/13)
The invention discloses a method for syn...
189005-44-5 Process route
-
![ethyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate](/upload/2024/12/26e6f8d7-4210-4747-8034-7b8c76c63ef2.png)
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193979-47-4
ethyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate
-
-
189005-44-5
6-methyl-2-(4-methylphenyl)-imidazo<1,2-a>pyridine-3-acetic acid
| Conditions | Yield |
|---|---|
|
With
water; potassium hydroxide;
In
ethanol;
at 30 ℃;
|
96% |
|
With
sodium hydroxide;
In
water;
for 3h;
Reflux;
|
81.8% |
|
With
water; sodium hydroxide;
In
ethanol;
at 90 ℃;
Flow reactor;
|
|
|
Multi-step reaction with 2 steps
1: pyrographite / ethanol / 20 °C
2: acetic acid / water; acetone / 0.5 h / 0 - 10 °C
With
pyrographite; acetic acid;
In
ethanol; water; acetone;
|
|
|
With
potassium hydroxide;
In
ethanol; water;
at 30 ℃;
|
|
|
With
lithium hydroxide monohydrate;
In
methanol; water;
at 20 ℃;
for 1h;
|
-
![N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide](/upload/2024/12/1da4ee84-82a6-4ecd-b75d-78d9542eb83b.png)
-
82626-48-0
N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
-
-
189005-44-5
6-methyl-2-(4-methylphenyl)-imidazo<1,2-a>pyridine-3-acetic acid
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
water;
at 0 ℃;
for 18h;
Heating / reflux;
|
94% |
189005-44-5 Upstream products
-
768398-03-4
6-methyl-3-cyanomethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine
-
365213-58-7
2-(4-methylphenyl)-6-methylimidazo[1,2-α]pyridine-3-acetamide
-
88965-00-8
6-methyl-2-(4-methyl-phenyl)-imidazo[1,2-a]pyridine
-
106961-33-5
dimethyl-(6-methyl-2-p-tolylimidazo[1,2-a]pyridin-3-ylmethyl)-amine
189005-44-5 Downstream products
-
82626-48-0
N,N,6-trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
-
851972-89-9
2-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-ethanol
-
851972-87-7
(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetyl chloride hydrochloride
-
851973-02-9
N-allyl-N-methyl-2-(6-methyl-2-p-tolyl-imidazo[1,2-a]pyridin-3-yl)-acetamide
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