35480-52-5
- Product Name：2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid
- Molecular Formula：C11H8F6O4
- Purity：99%
- Molecular Weight：318.173
Product Details
pd_meltingpoint:119-121 °C
Appearance:White crystal powder
Factory Sells Best Quality 2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid 35480-52-5 with steady supply
- Molecular Formula:C11H8F6O4
- Molecular Weight:318.173
- Appearance/Colour:White crystal powder
- Vapor Pressure:1.26E-05mmHg at 25°C
- Melting Point:119-121 °C
- Refractive Index:1.438
- Boiling Point:320.9 °C at 760 mmHg
- PKA:3.06±0.36(Predicted)
- Flash Point:147.9 °C
- PSA：55.76000
- Density:1.474 g/cm3
- LogP:3.26700
2,5-Bis(2,2,2-trifluoroethoxy)benzoic acid(Cas 35480-52-5) Usage
InChI:InChI=1/C11H8F6O4/c12-4-10(14,15)20-6-1-2-8(7(3-6)9(18)19)21-11(16,17)5-13/h1-3H,4-5H2,(H,18,19)
35480-52-5 Relevant articles
Preparation method of 2,5 - di (2,trifluoroethoxy) benzoic acid (by machine translation)
-
Paragraph 0026-0043; 0045, (2020/12/14)
The invention relates to the field of sy...
Production method of flecainide
-
Paragraph 0048; 0052; 0056-0057; 0061; 0065-0066; 0070; 0074, (2020/05/01)
The invention belongs to the technical f...
A practical ligand-free copper(I) bromide-catalyzed fluoroalkoxylation of unactivated aryl bromides
Guo, Ying,Li, Yu-Dao,Chen, Cheng,Zhao, Jian-Hong,Liu, Hong-Wei,Liao, Dao-Hua,Ji, Ya-Fei
, p. 2525 - 2537 (2016/03/16)
An efficient ligand-free fluoroalkoxylat...
Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor
Bannister, Mark L,Alvarez-Laviada, Anita,Thomas, N Lowri,Mason, Sammy A,Coleman, Sharon,du Plessis, Christo L,Moran, Abbygail T,Neill-Hall, David,Osman, Hasnah,Bagley, Mark C,MacLeod, Kenneth T,George, Christopher H,Williams, Alan J
supporting information, p. 2446 - 2459 (2016/11/18)
Background and Purpose: Flecainide is a ...
35480-52-5 Process route
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847786-18-9
5-bromo-2-(2,2,2-trifluoroethoxy)benzoic acid
-
-
75-89-8
2,2,2-trifluoroethanol
-
-
35480-52-5
2,5-di-(2,2,2-trifluoroethoxy)benzoic acid
| Conditions | Yield |
|---|---|
|
2,2,2-trifluoroethanol;
With
sodium t-butanolate;
In
DMF (N,N-dimethyl-formamide);
at 0 - 25 ℃;
for 1h;
5-bromo-2-(2,2,2-trifluoroethoxy)benzoic acid;
copper(I) bromide;
In
DMF (N,N-dimethyl-formamide);
at 100 ℃;
for 10h;
|
75.3% |
-
![1-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]ethanone](/upload/2024/12/4b36577b-2ddc-452e-8492-b3728fa985bf.png)
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1-[2,5-bis(2,2,2-trifluoroethoxy)phenyl]ethanone
-
-
35480-52-5
2,5-di-(2,2,2-trifluoroethoxy)benzoic acid
| Conditions | Yield |
|---|---|
|
With
sodium hypochlorite; sodium hydroxide;
In
water;
at 95 ℃;
for 9h;
Sealed tube;
|
89% |
|
With
sodium hypochlorite;
In
1,4-dioxane;
at 35 ℃;
for 3h;
|
35480-52-5 Upstream products
-
75-89-8
2,2,2-trifluoroethanol
-
21739-92-4
5-bromo-2-chlorobenzoic acid
-
1023951-32-7
2,5-bis(2,2,2-trifluroethoxy)toluene
-
847786-18-9
5-bromo-2-(2,2,2-trifluoroethoxy)benzoic acid
35480-52-5 Downstream products
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35480-31-0
methyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate
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50778-59-1
2,5-bis(2,2,2-trifluoroethoxy)benzoic acid chloride
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57415-36-8
2,5-bis(2,2,2-trifluoroethoxy)-N-(pyridin-2-ylmethyl)-benzamide
-
50778-75-1
2,5-di-(2,2,2-trifluoroethoxy)benzoic acid hydrazide
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