59045-82-8
- Product Name：(S)-(+)-Nipecotic acid
- Molecular Formula：C6H11NO2
- Purity：99%
- Molecular Weight：129.159
Product Details
pd_meltingpoint:254 °C (dec.)
Excellent chemical plant bulk supply (S)-(+)-Nipecotic acid 59045-82-8
- Molecular Formula:C6H11NO2
- Molecular Weight:129.159
- Melting Point:254 °C (dec.)
- Refractive Index:4.5 ° (C=5, H2O)
- Boiling Point:265.8 °C at 760 mmHg
- PKA:3.88±0.20(Predicted)
- Flash Point:114.5 °C
- PSA：49.33000
- Density:1.125 g/cm3
- LogP:0.39940
59045-82-8 Relevant articles
Catalytic Asymmetric Synthesis of Unprotected β2-Amino Acids
Zhu, Chendan,Mandrelli, Francesca,Zhou, Hui,Maji, Rajat,List, Benjamin
supporting information, p. 3312 - 3317 (2021/04/07)
We report here a scalable, catalytic one...
Method for preparing (S)-3-piperidinecarboxylic acid
-
Paragraph 0025-0030; 0036; 0039; 0041, (2017/08/29)
The invention discloses a method for pre...
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Futatsugi, Kentaro,Kung, Daniel W.,Orr, Suvi T. M.,Cabral, Shawn,Hepworth, David,Aspnes, Gary,Bader, Scott,Bian, Jianwei,Boehm, Markus,Carpino, Philip A.,Coffey, Steven B.,Dowling, Matthew S.,Herr, Michael,Jiao, Wenhua,Lavergne, Sophie Y.,Li, Qifang,Clark, Ronald W.,Erion, Derek M.,Kou, Kou,Lee, Kyuha,Pabst, Brandon A.,Perez, Sylvie M.,Purkal, Julie,Jorgensen, Csilla C.,Goosen, Theunis C.,Gosset, James R.,Niosi, Mark,Pettersen, John C.,Pfefferkorn, Jeffrey A.,Ahn, Kay,Goodwin, Bryan
supporting information, p. 7173 - 7185 (2015/10/05)
The medicinal chemistry and preclinical ...
Characterization of an enantioselective amidase from Cupriavidus sp. KNK-J915 (FERM BP-10739) useful for enzymatic resolution of racemic 3-piperidinecarboxamide
Nojiri, Masutoshi,Taoka, Naoaki,Yasohara, Yoshihiko
, p. 136 - 142 (2014/12/10)
A novel amidase (CsAM) acting on (R,S)-N...
59045-82-8 Process route
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-
163438-09-3
(R)-1-Boc-nipecotic acid
-
-
498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(R)-nipecotic acid
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
dichloromethane;
at 30 ℃;
for 2h;
Solvent;
|
|
|
With
hydrogenchloride;
In
1,4-dioxane; dichloromethane;
at 30 ℃;
for 2h;
|
-
-
498-96-4
guvacine
-
-
498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(R)-nipecotic acid
| Conditions | Yield |
|---|---|
|
With
C63H78IrNOP(2+)*C32H12BF24(1-); hydrogen;
In
methanol;
at 60 ℃;
for 12h;
under 4560.31 Torr;
enantioselective reaction;
Autoclave;
|
99% |
59045-82-8 Upstream products
-
25137-01-3
(R)-ethyl nipecotate
-
498-95-3
nipecotic acid
-
251948-99-9
(-)-(R)-N-tert-butyloxycarbonyl-1,2,3,6-tetrahydropyridin-3-carboxylic acid
-
614-18-6
3-pyridinecarboxylic acid ethyl ester
59045-82-8 Downstream products
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193693-68-4
(S)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}piperidine-3-carboxylic acid
-
193693-67-3
(R)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}piperidine-3-carboxylic acid
-
163438-09-3
(R)-1-Boc-nipecotic acid
Relevant Products
-
1-Boc-3-PiperidinoneCAS：98977-36-7
-
benzyl (2-bromoethyl)carbamateCAS：53844-02-3
-
Methyl-DL-serine hydrochlorideCAS：5619-04-5
