98319-26-7
- Product Name：Finasteride
- Molecular Formula：C23H36N2O2
- Purity：99%
- Molecular Weight：372.551
Product Details
pd_meltingpoint:253 °C
Appearance:white to off-white crystalline powder
Quality products make an important contribution to long-term revenue and profitability. Manufacturer supply top purity Finasteride 98319-26-7 with GMP standards
1.What is the Finasteride ?
Finasteride (Proscar) is a 5-reductase inhibitor that blocks the conversion of testosterone to DHT in target tissues. Since DHT is the major intracellular androgen in the prostate, finasteride is effective in suppressing DHT stimulation of prostatic growth and secretory function without markedly affecting libido. It is approved for the treatment of benign prostatic hyperplasia. Although there is usually some regression in the size of the prostate gland following administration of finasteride, clinical response may take 6 to 12 months. If the obstructive symptoms are severe, there is often not enough time to allow this compound to work.The principal adverse effects of finasteride are impotence, decreased libido, and decreased volume of ejaculate. The compound is generally well tolerated in men.
Finasteride is an antialopecia agent that Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. It is used to treatment of benign prostatic hyperplasia and androgenetic alopecia.
-
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98319-24-5
dihydro-finasteride
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98319-26-7,140375-21-9,140375-22-0
finasteride
| Conditions | Yield |
|---|---|
|
With
2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
1,4-dioxane;
for 18h;
Heating;
|
70.5% |
|
With
benzeneseleninic anhydride;
In
chlorobenzene;
for 10h;
Heating;
|
40.36% |
|
With
bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
1,4-dioxane;
Yield given;
20 deg C, 4 h. then 110 deg C, 18 h.;
|
|
|
With
benzeneseleninic anhydride;
In
chlorobenzene;
for 4h;
Heating;
|
|
|
With
HYDROCORTISONE; 13-ethyl-10,11α-dihydroxy-gon-4-ene-3,17-dione; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE; menadione bisulfite; estra-4-ene-3,17-dione;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; 13-ethyl-10,11α-dihydroxy-gon-4-ene-3,17-dione;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE; 13-ethyl-10,11α-dihydroxy-gon-4-ene-3,17-dione;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE; 13-ethyl-10,11α-dihydroxy-gon-4-ene-3,17-dione; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE; 13-ethyl-10,11α-dihydroxy-gon-4-ene-3,17-dione; menadione bisulfite;
Bacillus subtilis (NRRL B-3683);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; 13-ethyl-10,11α-dihydroxy-gon-4-ene-3,17-dione; menadione bisulfite;
Mycobacterium sp. (NRRL B-3683);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; 13-ethyl-10,11α-dihydroxy-gon-4-ene-3,17-dione; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE; 11-α-acetyloxyestr-4-ene-3,17-dione; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; menadione bisulfite; 11α-hydroxy-estr-4-ene-3,17-dione;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; 11α-acetoxy-13-ethyl-4-gonene-3,17-dione; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; menadione bisulfite; 13β-ethyl-11α-hydroxygon-5-ene-3,17-dione;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 32 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
pH=7.5 - 7.7;
|
|
|
With
HYDROCORTISONE; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; menadione bisulfite;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
HYDROCORTISONE; menadione bisulfite; 13β-ethyl-gon-4-en-3,17-dione;
Arthrobacter simplex (ATCC 6946);
In
methanol; ethanol;
at 30 ℃;
for 72h;
|
|
|
With
benzeneseleninic anhydride;
In
toluene;
at 110 - 112 ℃;
for 18h;
|
|
|
dihydro-finasteride;
With
N,O-Bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
toluene;
at 93 ℃;
for 6h;
With
sodium sulfite;
In
water; toluene;
at 55 - 70 ℃;
|
|
|
With
BSTFA; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
|
|
|
Multi-step reaction with 2 steps
1.1: N,N,N,N,-tetramethylethylenediamine; chloro-trimethyl-silane / dichloromethane / 0.33 h / 0 °C / Inert atmosphere
1.2: 0 - 5 °C / Inert atmosphere
2.1: sodium hydrogencarbonate; Oxone / methanol; water / 30 °C
With
Oxone; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; sodium hydrogencarbonate;
In
methanol; dichloromethane; water;
|
|
|
dihydro-finasteride;
With
N,O-Bis(trimethylsilyl)trifluoroacetamide; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
toluene;
for 6h;
Reflux;
With
sodium hydrogensulfite;
In
toluene;
at 45 ℃;
for 0.5h;
With
sodium tetrahydroborate; sodium thiosulfate;
In
water; toluene;
at 40 ℃;
for 0.5h;
Temperature;
Reagent/catalyst;
|
9.16 g |
-
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684215-49-4
N-tert-butyl-2-phenylsulfenyl-3-oxo-4-aza-5α-androstane-17β-carboxamide
-
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98319-26-7,140375-21-9,140375-22-0
finasteride
| Conditions | Yield |
|---|---|
|
With
sodium periodate;
In
methanol; water;
at 20 ℃;
for 6h;
|
86% |
|
N-tert-butyl-2-phenylsulfenyl-3-oxo-4-aza-5α-androstane-17β-carboxamide;
With
sodium periodate;
In
methanol; water;
at 20 ℃;
for 16h;
In
xylene;
for 2h;
Heating / reflux;
|
2.What is the CAS number for Finasteride ?
The CAS number of Finasteride is 98319-26-7.
More information of Finasteride 98319-26-7 are:
|
CAS Number |
98319-26-7 |
|
Density |
1.065 g/cm3 |
|
Melting Point |
253 °C |
|
Boiling Point |
576.6 °C at 760 mmHg |
|
Flash Point |
177.4 °C |
|
Vapor Pressure |
0mmHg at 25°C |
|
Refractive Index |
1.524 |
|
HS CODE |
29379000 |
|
PSA |
58.20000 |
|
LogP |
4.53420 |
|
Pka |
14.17±0.70(Predicted) |
3.What are another words for Finasteride ?
Synonyms for Finasteride 98319-26-7:Proscar (TN);Finasteride (USP);Finpecia;4-Azaandrost-1-ene-17-carboxamide, N-(1,1-dimethylethyl)-3-oxo-, (5alpha,17beta)-;Proscar;Finastid;Propecia (TN);Propecia;MK-0906;MK 906;Finasteride [USAN:BAN:INN];MK-906;Prostide;Chibro-Proscar;Finasterida [INN-Spanish];Finasteridum [INN-Latin];N-tert-butyl-4-aza-5alpha-androsta-3-oxo-17beta-carboxamide;Finasteride 99%;
4.What is the molecular formula of Finasteride?
The chemical formula of Finasteride is C23H36N2O2 which containing 23 Carbon atoms,36 Hydrogen atoms,2 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of Finasteride is 372.551.
5.What is Finasteride (98319-26-7) used for?
Finasteride, a novel 4-azasteroid, is a breakthrough in the treatment and control of benign prostatic hyperplasia. Mechanistically, it inhibits the prostatic-specific enzyme 5-alpha reductase, thereby decreasing the conversion of testosterone to dihydrotestosterone. It is reportedly effective in reducing urinary symptoms and prostatic volume and increasing maximal urinary flow rate. Finasteride is also being investigated as a treatment for prostatic cancer.
InChI:InChI=1/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18?,22-,23+/m0/s1
Relevant articles related to Finasteride:
|
Article |
Source |
|
Method for forming double bonds between 1-position and 2-position during synthesis of finasteride and dutasteride |
- , (2016/12/01) |
|
Crystallization engineering in aza-steroid: Application in the development of finasteride |
Bhattacharya, Apurba,Manudhane, Kushal S,Maddula, Srinivasula Reddy,Sreekanth,Thota, Sridhar,Bandichhor, Rakeshwar , p. 599 - 602 (2013/06/05) |
6.Buy Finasteride with the best price .
HANGZHOU YUNUO CHEMICAL CO.,LTD is a quality supplier of Finasteride. Our main goal is customer satisfaction. Contact us to negotiate the best price for your business on Finasteride 98319-26-7.
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